pyruvate kinase inhibitor TLN-232

Definition / meaning of pyruvate kinase inhibitor TLN-232

A synthetic cyclic heptapeptide with potential antineoplastic activity. Pyruvate kinase (PK) inhibitor TLN-232 targets pyruvate kinase M2 (M2PK), which may disrupt tumor cell anaerobic glycolysis. M2PK is a dimeric isoform of PK and the predominant PK isoform found in tumor cells.

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The Web site of the National Cancer Institute (http://www.cancer.gov/)

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