pyroxamide

Definition / meaning of pyroxamide

A synthetic derivative of hydroxamic acid with antineoplastic properties, Pyroxamide inhibits histone deacetylases involved in transcription; induces hyperacetylation of core histones, modulating chromatin structure and affecting transcription of some genes that inhibit tumor growth; and induces growth arrest and apoptosis. Pyroxamide is used in clinical studies for cancer chemotherapy.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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