pyrazoloacridine

Definition / meaning of pyrazoloacridine

A 9-methoxy acridine compound containing a reducible 5-nitro substituent. Pyrazoloacridine appears to intercalate into DNA and inhibit RNA synthesis, DNA synthesis, and the activities of topoisomerases I and II, thereby causing cytotoxicity.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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