pyrazofurin

Definition / meaning of pyrazofurin

A nucleoside analog. Pyrazofurin potently inhibits orotidine 5′-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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