pTVG-HP plasmid DNA vaccine

Definition / meaning of pTVG-HP plasmid DNA vaccine

A cancer vaccine containing plasmid DNA encoding human prostatic acid phosphatase (PAP) (pTVG-HP) with potential immunostimulatory and antineoplastic activities. Upon administration, pTVG-HP plasmid DNA vaccine may stimulate the host immune system to generate a cytotoxic T lymphocyte (CTL) response against PAP-expressing prostate cancer cells. PAP or prostatic specific acid phosphatase (PSAP) is a tumor associated antigen (TAA) that may be overexpressed in prostate cancer.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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