PSA RNA-pulsed dendritic cell vaccine

Definition / meaning of PSA RNA-pulsed dendritic cell vaccine

An autologous dendritic cell vaccine with potential immunostimulatory activity. Dendritic cells harvested from a prostate cancer patient are transfected with the mRNA encoding for prostate specific antigen (PSA), a tumor marker secreted by prostatic epithelial and ductal cells. When reintroduced back to the patient, these PSA RNA pulsed autologous dendritic cells may elicit a cytotoxic T-cell (CTL) response against PSA-positive prostate cancer cells.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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