pixantrone dimaleate

Definition / meaning of pixantrone dimaleate

The dimaleate salt of a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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