piperazinedione

Definition / meaning of piperazinedione

A crystalline antibiotic fermentation product isolated from the bacterium Streptomyces griseoluteus with antineoplastic activity. Piperazinedione alkylates DNA at the N-7 position of guanine, inhibiting DNA replication and inducing cell cycle arrest.

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Find More About 'piperazinedione'

Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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