pemetrexed disodium

Definition / meaning of pemetrexed disodium

The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2′-deoxyuridine-5′-monophosphate (dUMP) to 2′-deoxythymidine-5′-monophosphate (dTMP), an essential precursor in DNA synthesis.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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