pegylated anti-GFR antibody fragment

Definition / meaning of pegylated anti-GFR antibody fragment

A pegylated, cross-linked, humanized divalent-Fab’ antibody fragment directed against vascular endothelial growth factor receptor-2 (VEGFR-2) with potential antiangiogenic and antitumor activities. Pegylated anti-GFR antibody fragment binds to and inhibits VEGFR-2, which may inhibit angiogenesis and tumor cell proliferation. Multivalent Fab’ antibody fragments may exhibit improved retention and internalization properties compared to their parent IgGs.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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