pazopanib hydrochloride

Definition / meaning of pazopanib hydrochloride

The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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