PAK4 inhibitor PF-03758309

Definition / meaning of PAK4 inhibitor PF-03758309

An orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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