nelarabine

Definition / meaning of nelarabine

An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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