nedaplatin

Definition / meaning of nedaplatin

A second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.

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Find More About 'nedaplatin'

Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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