lutetium Lu 177 monoclonal antibody J591

Definition / meaning of lutetium Lu 177 monoclonal antibody J591

A radioimmunoconjugate consisting of a humanized monoclonal antibody directed against the extracellular domain of prostate-specific membrane antigen linked to a beta-emitting radioisotope (lutetium-177). This radioimmunoconjugate binds to tumor cells that express the extracellular domain of prostate-specific membrane antigen, delivering beta particle radiation selectively to tumor cells expressing this antigen and so limiting the exposure of normal tissues to ionizing radiation.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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