LMB-7 immunotoxin

Definition / meaning of LMB-7 immunotoxin

A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin attaches to B3, a Lewis Y-related carbohydrate epitope on some solid tumor cells. The antibody attaches to the cell and the exotoxin inhibits protein synthesis by inactivating elongation factor 2.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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