KW 2189

Definition / meaning of KW 2189

A semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2. Activated by carboxyl esterase, KW 2189 alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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