KW-2149

Definition / meaning of KW-2149

A semisynthetic water-soluble disulfide derivative of the antineoplastic antibiotic mitomycin C. Activated by serum and glutathione, KW-2149 causes interstrand DNA cross-links and DNA-protein cross-links, resulting in single-strand DNA breaks and inhibition of DNA synthesis.

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Find More About 'KW-2149'

Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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