ketoconazole

Definition / meaning of ketoconazole

A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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