karenitecin

Definition / meaning of karenitecin

A synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Karenitecin stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, karenitecin exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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