ISIS 3521

Definition / meaning of ISIS 3521

A synthetic phosphorothioate oligodeoxynucleotide. As an antisense molecule, ISIS 3521 hybridizes to the 3-untranslated region of the human protein kinase C (PKC-alpha) mRNA, thereby inhibiting PKC-alpha expression and growth of PKC-alpha-dependent tumor cells.

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Find More About 'ISIS 3521'

Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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