inosine dialdehyde

Definition / meaning of inosine dialdehyde

A toxic purine analogue. Inosine dialdehyde inhibits ribonucleotide reductase, resulting in decreased synthesis of DNA, RNA, and proteins, and G2/M-phase cell cycle arrest. This agent also forms stable covalent crosslinks in proteins, thereby inhibiting the activity of enzymes involved in nucleic acid synthesis.

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The Web site of the National Cancer Institute (http://www.cancer.gov/)

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