indium I 111 chimeric monoclonal antibody G250

Definition / meaning of indium I 111 chimeric monoclonal antibody G250

A radioimmunoconjugate comprised of the chimeric monoclonal antibody G250 conjugated with the gamma-emitting radioisotope indium In 111. Indium I 111 chimeric monoclonal antibody G250 binds to G250, allowing the localization of G250-expressing tumor cells using gamma scintigraphy.Found in the majority of renal cell carcinomas (RCCs), G250 or carbonic anhydrase isozyme IX (CA IX) is a cell surface tumor-associated antigen (TAA).

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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