imidazole mustard

Definition / meaning of imidazole mustard

A synthetic derivative of imidazole with potent antineoplastic properties. Imidazole mustard alkylates DNA, preferentially at guanine residues, resulting in DNA interstrand crosslinks and inhibition of DNA replication and RNA and protein synthesis.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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