ifosfamide

Definition / meaning of ifosfamide

A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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