gp96-Ig fusion protein-expressing non-small cell lung cancer cell vaccine

Definition / meaning of gp96-Ig fusion protein-expressing non-small cell lung cancer cell vaccine

A cancer vaccine consisting of irradiated non-small cell lung cancer cells, manipulated to express and secrete heat shock protein gp96-Ig fusion protein, with potential antineoplastic activity. Vaccination with gp96-Ig fusion protein-expressing non-small cell lung cancer cell vaccine may elicit a cytotoxic T cell response against non-small lung cancer cells. Monomorphic heat shock protein gp96 participates in the major histocompatibility complex class I-restricted antigen presentation pathway.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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