gp100:280-288(288V) peptide vaccine

Definition / meaning of gp100:280-288(288V) peptide vaccine

A peptide vaccine consisting of the amino acids 280 through 288 of the melanoma antigen glycoprotein 100 (gp100) with potential antineoplastic activity. gp100:280-288(288V) peptide has a valine substitution at amino acid position 288 to improve immunogenicity. Vaccination with gp100:280-288(288V) peptide may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the gp100 antigen, resulting in decreased tumor growth.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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