gimeracil

Definition / meaning of gimeracil

A pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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