Ga-68-labeled F(ab’) 2- trastuzumab

Definition / meaning of Ga-68-labeled F(ab’) 2- trastuzumab

A radioimmunoconjugate consisting of a trastuzumab fragment labeled with the positron-emitting radioisotope gallium Ga 68 with radioisotopic and antibody activities. Upon administration, Ga-68-labeled F(ab’)2-trastuzumab may bind to HER2-positive tumor cells, allowing radioimmunolocalization with positron emission tomography (PET). Trastuzumab is a recombinant humanized monoclonal antibody that selectively binds to the extracellular domain of human epidermal growth factor receptor 2 (HER2), overexpressed by many adenocarcinomas, particularly breast adenocarcinomas.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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