FAK inhibitor PF-04554878

Definition / meaning of FAK inhibitor PF-04554878

An orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival. The tyrosine kinase FAK is , a signal transducer for integrins that is upregulated in many tumor cell types and is involved in tumor cell invasion, migration and proliferation.

Listed under:

Find More About 'FAK inhibitor PF-04554878'


The Web site of the National Cancer Institute (http://www.cancer.gov/)

Leave a Comment