edotecarin

Definition / meaning of edotecarin

A synthetic indolocarbazole with antineoplastic activity. Edotecarin inhibits the enzyme topoisomerase I through stabilization of the DNA-enzyme complex and enhanced single-strand DNA cleavage, resulting in inhibition of DNA replication and decreased tumor cell proliferation.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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