echinomycin

Definition / meaning of echinomycin

A polypeptide quinoxaline antineoplastic antibiotic isolated from the bacterium Streptomyces echinatus. Echinomycin intercalates into DNA at two locations simultaneously in a sequence-specific fashion, thereby inhibiting DNA replication and RNA synthesis.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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