DNA minor groove-binding agent PM01183

Definition / meaning of DNA minor groove-binding agent PM01183

A synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. DNA minor groove-binding agent PM01183 covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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