dimesna

Definition / meaning of dimesna

1) A synthetic derivative of dithio-ethane sulfonate with uroprotective properties. In the kidney, dimesna undergoes reduction to the free thiol compound, mesna, which reacts chemically with the urotoxic ifosfamide metabolites acrolein and 4-hydroxy-ifosfamide, resulting in their detoxification. This agent also inhibits cyclophosphamide-induced hemorrhagic cystitis.

2) A drug that belongs to the family of drugs called chemoprotective agents.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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