deoxycytidine analogue TAS-109

Definition / meaning of deoxycytidine analogue TAS-109

An analogue of the nucleoside deoxycytidine with potential antineoplastic activity. Nucleoside analogue TAS-109 is incorporated into DNA and directly inhibits the activity of DNA polymerase, which may result in inhibition of DNA replication and cell cycle arrest in the S and G2/M phases, DNA fragmentation, and tumor cell apoptosis.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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