dactinomycin

Definition / meaning of dactinomycin

A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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