cisplatin

Definition / meaning of cisplatin

An inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition.

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Find More About 'cisplatin'

Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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