chromomycin A3

Definition / meaning of chromomycin A3

A glycosidic antineoplastic antibiotic isolated from the bacterium Streptomyces griseus. Chromomycin A3 reversibly binds to guanine-cytosine (G-C) base pairs in the minor groove of DNA, thereby inhibiting RNA synthesis. This agent is used as a fluorescent chromosome dye.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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