cell cycle checkpoint / DNA repair antagonist IC83

Definition / meaning of cell cycle checkpoint / DNA repair antagonist IC83

A proprietary agent with potential antineoplastic activity. Cell cycle checkpoint/DNA repair antagonist IC83 IC83 inhibits cell cycle checkpoint/DNA repair enzymes, which may result in enhanced cytotoxicity of DNA damaging agents and diminished tumor cell resistance to chemotherapy and radiation therapy.Cell cycle checkpoint/DNA repair enzymes are involved in the recognition and repair of damaged DNA and are overexpressed in many types of cancer cells.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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