bisantrene hydrochloride

Definition / meaning of bisantrene hydrochloride

The hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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