autologous TARP peptide-pulsed dendritic cell vaccine

Definition / meaning of autologous TARP peptide-pulsed dendritic cell vaccine

A cell-based cancer vaccine comprised of autologous dendritic cells pulsed with autologous T cell receptor gamma-chain alternate reading frame protein (TARP) peptide with potential immunostimulatory and antineoplastic activities. Upon intradermal administration, autologous TARP peptide-pulsed dendritic cell vaccine may stimulate anti-tumoral cytotoxic T lymphocyte (CTL) and antibody responses against TARP-expressing cancer cells, resulting in tumor cell lysis. The highly immunogenic nuclear protein TARP is commonly expressed in breast and prostate cancer cells.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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