autologous dendritic cell-tumor fusion vaccine

Definition / meaning of autologous dendritic cell-tumor fusion vaccine

A therapeutic cancer vaccine consisting of autologous dendritic cells (DCs) fused with autologous tumor cells with potential immunostimulatory and antineoplastic activities. Autologous dendritic cell-tumor fusion vaccine is generated in vitro by mixing DCs and irradiated tumor cells harvested from individual patients and treating them with polyethylene glycol (PEG) to produce DC-tumor cell fusion hybrid cells. Upon administration, autologous dendritic cell-tumor fusion vaccine may elicit antitumor humoral and cellular immune responses.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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