autologous dendritic cell-adenovirus p53 vaccine

Definition / meaning of autologous dendritic cell-adenovirus p53 vaccine

An autologous vaccine composed of dendritic cells (DC) that have been transduced with a p53 tumor suppressor gene-modified virus. When the autologous dendritic cell-adenovirus p53 vaccine is administered, the host cytotoxic T lymphocytes (CTL) are directed against p53-positive tumor cells, which may result in tumor cell death and decreased tumor growth.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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