Aurora kinase inhibitor BI 811283

Definition / meaning of Aurora kinase inhibitor BI 811283

A small molecule inhibitor of the serine/threonine protein kinase Aurora kinase with potential antineoplastic activity. Aurora kinase inhibitor BI 811283 binds to and inhibits Aurora kinases, resulting in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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