anti-mesothelin monoclonal antibody MORAb-009

Definition / meaning of anti-mesothelin monoclonal antibody MORAb-009

A humanized IgG1 monoclonal antibody directed against human mesothelin with potential antineoplastic activity. Anti-mesothelin monoclonal antibody MORAb-009 binds to mesothelin, triggering an antibody dependent cellular cytotoxicity (ADCC)-mediated host immune response against mesothelin-expressing tumor cells, which may result in tumor cell lysis. Mesothelin, a 40kDa cell surface glycoprotein, is overexpressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinomas.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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