anti-endosialin / TEM1 monoclonal antibody MORAb-004

Definition / meaning of anti-endosialin / TEM1 monoclonal antibody MORAb-004

A humanized IgG1 monoclonal antibody directed against human endosialin/TEM1 (tumor endothelial marker;CD248) with potential anti-angiogenic and antineoplastic activities. Anti-endosialin/TEM1 monoclonal antibody MORAb-004 binds to and inhibits the activity of cell surface protein endosialin/TEM1, which may result in the inhibition of angiogenesis, tumor cell proliferation and metastasis. Endosialin/TEM1 plays a key role in angiogenesis and may be overexpressed on tumor stromal cells and endothelial cells.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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