amoxicillin-clavulanate potassium

Definition / meaning of amoxicillin-clavulanate potassium

A combination of the semisynthetic broad-spectrum antibiotic amoxicillin and the beta-lactamase enzyme inhibitor clavulanate potassium. Clavulanate potassium increases the serum half-life of amoxicillin by inhibiting beta-lactamase-mediated metabolism of amoxicillin. Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin binding proteins and inhibiting peptidoglycan synthesis, a critical component of bacterial cell walls.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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