amonafide dihydrochloride

Definition / meaning of amonafide dihydrochloride

The dihydrochloride salt of amonafide, an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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