aminothiadiazole

Definition / meaning of aminothiadiazole

A synthetic derivative of nicotinamide adenine dinucleotide (NAD). Aminothiadiazole competitively inhibits inosine 5-monophosphate dehydrogenase, thereby disrupting the regulation of cell proliferation and differentiation in a number of cells. This agent is also a selective human adenosine A3 receptor antagonist.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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