altretamine

Definition / meaning of altretamine

A synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage.

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Source(s):

The Web site of the National Cancer Institute (http://www.cancer.gov/)

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